![]() Viruses cause a wide range of human diseases, ranging from acute self-healing conditions to acute fatal diseases. Herein, we also offer an insight into the underlying mechanisms of the therapeutic effects of TCM, as well as introduce new naturally occurring compounds with anti-coronavirus activity, in order to provide a new and potential drug development strategy for the treatment of COVID-19. In this article, we summarize the current applications of TCM in the treatment of COVID-19 patients. As an important part of medical practice, TCM showed an obvious therapeutic effect in SARS-CoV-infected patients. However, there is no specific medicine which is available to treat the disease. For SARS, there is no correlation between viral load and worsening symptoms. Both coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) are characterized by excessive inflammatory response. Excessive production of IL-1β is related to inflammatory and autoimmune diseases. IL-1β was originally identified as a pro-inflammatory cytokine, capable of inducing local and systemic inflammation as well as a fever response reaction in response to infection or injury. ![]() ![]() Inflammasomes are large multimolecular complexes best recognized because of their ability to control activation of caspase-1, which in turn regulates the maturation of interleukin-18 (IL-18) and interleukin-1 β (IL-1β). ![]()
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